Staurosporine
Cat. No.：YN310259
CAS No. ：62996-74-1
| 产品名称: | Staurosporine |
| CAS No.: | 62996-74-1 |
| Chemical Name: | 2,3,10,11,12,13-hexahydro-10R-methoxy-9S-methyl-11R-methylamino-9S,13R-epoxy-1H,9H-diindolo[1,2,3-gh;3’,2’,1’-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one |
| Synonyms: | 星形孢菌素; Antibiotic AM-2282; STS; AM-2282 |
| 分子量: | 466.53 |
| 分子式: | C₂₈H₂₆N₄O₃ |
| SMILES: | O=C(NC1)C2=C1C3=C(C4=C2C5=C(C=CC=C5)N4[C@H]6C[C@@H](NC)[C@@H](OC)[C@]7(C)O6)N7C8=CC=CC=C83 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Staurosporine 是一种有效，非选择性蛋白激酶抑制剂，抑制PKC，PKA，c-Fgr，和Phosphorylase kinase的IC50分别为 6 nM，15 nM，2 nM，3 nM。Staurosporine 是一个凋亡诱导剂。 |
| IC50和靶点: | [{name:"PKC:6 nM (IC50)"},{name: "PKA:15 nM (IC50)"},{name: "c-Fgr:2 nM (IC50)"},{name: "Phosphorylase kinase:3 nM (IC50)"},{name: "S6 kinase (70 kDa):5 nM (IC50)"},{name: "v-Src:6 nM (IC50)"},{name: "cdc2:9 nM (IC50)"},{name: "TPK-IIB/Syk:16 nM (IC50)"},{name: "Ca2+/CaM PK-I1:20 nM (IC50)"},{name: "MLCK:21 nM (IC50)"},{name: "IR:61 nM (IC50)"},{name: "EGF-R:100 nM (IC50)"},{name: "ERK-1:1500 nM (IC50)"},{name: "CSK:2000 nM (IC50)"},{name: "IGF-IR:6150 nM (IC50)"},{name: "CK2:19500 nM (IC50)"},{name: "CK1:163500 nM (IC50)"}] |
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Tamaoki, T., Nomoto, H., Takahashi, I., et al.Staurosporine, a potent inhibitor of phospholipid/Ca++ dependent protein kinaseBiochem. Biophys. Res. Commun.135,397-402(1986)
McGlynn, E., Liβz, J., Reutener, S., et al.Expression and partial characterization of rat protein kinase C-δ and protein kinase C-ζ in insect cells using recombinant baculovirusJ. Cell. Biochem.49,239-250(1992)
Ruegg, U.T., and Burgess, G.M.Staurosporine, K-252 and UCN-01: Potent but nonspecific inhibitors of protein kinasesTrends Pharmacol. Sci.10,218-220(1989)
Li, H., and Förstermann, U.Structure-activity relationship of staurosporine analogs in regulating expression of endothelial nitric-oxide synthase geneMol. Pharmacol.57,427-435(1999)
