Afuresertib hydrochloride
Cat. No.：YN310280
CAS No. ：1047645-82-8
| 产品名称: | Afuresertib hydrochloride |
| CAS No.: | 1047645-82-8 |
| Chemical Name: | N-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, monohydrochloride |
| Synonyms: | GSK2110183 hydrochloride |
| 分子量: | 463.78 |
| 分子式: | C₁₈H₁₈Cl₃FN₄OS |
| SMILES: | O=C(C1=CC(C2=C(Cl)C=NN2C)=C(Cl)S1)N[C@@H](CC3=CC=CC(F)=C3)CN.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Afuresertib hydrochloride (GSK 2110183 hydrochloride) 是一个口服有效的，ATP 竞争性的选择性pan-Akt抑制剂，作用于Akt1/Akt2/Akt3，Ki值分别为 0.08/2/2.6 nM。 |
| IC50和靶点: | [{name:"Akt1:0.08 nM (Ki)"},{name: "Akt2:2 nM (Ki)"},{name: "Akt3:2.6 nM (Ki)"},{name: "Akt1 E17K mutant:0.2 nM (IC50)"},{name: "PKCη:210 nM (IC50)"},{name: "PKC-βI:430 nM (IC50)"},{name: "ROCK:100 nM (IC50)"},{name: "PKCθ:510 nM (IC50)"}] |
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| Solvent & Solubility: |
Dumble, M., Crouthamel, M.C., Zhang, S.Y., et al.Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitorPLoS One9(6),e100880(2014)
