TAS-301
Cat. No.：YN310312
CAS No. ：193620-69-8
| 产品名称: | TAS-301 |
| CAS No.: | 193620-69-8 |
| Chemical Name: | 3-[bis(4-methoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one |
| Synonyms: | TAS 301 |
| 分子量: | 357.40 |
| 分子式: | C₂₃H₁₉NO₃ |
| SMILES: | O=C1NC2=C(C=CC=C2)/C1=C(C3=CC=C(OC)C=C3)/C4=CC=C(OC)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TAS-301 是一种平滑肌迁移和增殖抑制剂，能够抑制 PDGF 诱导的PKC的活化。 |
| IC50和靶点: | |
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Sasaki, E., Miyoshi, K., Nozawa, Y., et al.Tas-301, a new synthetic inhibitor of neointimal thickening after balloon injury, inhibits calcium-dependent signal transduction and cytoskeletal reorganizationPharmacology63(1),17-27(2001)
Sasaki, E., Nozawa, Y., Miyoshi, K., et al.TAS-301 blocks receptor-operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth factor and platelet-derived growth factorJpn. J. Pharmacol.84(3),252-258(2000)
Muranaka, Y., Yamasaki, Y., Nozawa, Y., et al.TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteriesJ. Pharmacol. Exp. Ther.285(3),1280-1286(1998)
Sasaki, E., Tanahashi, Y., Yamasaki, Y., et al.Inhibitory effect of TAS-301, a new synthesized constrictive remodeling regulator, on renarrowing after balloon overstretch injury of porcine coronary arteryJ. Pharmacol. Exp. Ther.295(3),1043-1050(2000)
