Rottlerin
Cat. No.：YN310314
| 产品名称: | Rottlerin |
| CAS No.: | 82-08-6 |
| Chemical Name: | (2E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one |
| Synonyms: | Mallotoxin; NSC 56346; NSC 94525 |
| 分子量: | 516.54 |
| 分子式: | C₃₀H₂₈O₈ |
| SMILES: | O=C(C1=C2C(C=CC(C)(C)O2)=C(O)C(CC3=C(O)C(C)=C(O)C(C(C)=O)=C3O)=C1O)/C=C/C4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Rottlerin 是可从Mallotus Philippinensis中的到的一种天然产物， 是 PKC 的一个特异性抑制剂，其对PKCδ的IC50值为 3-6 μM， PKCα,β,γ 的为 30-42 μM，PKCε,η,ζ 为 80-100 μM。Rottlerin 可作为线粒体直接解偶联剂，通过编写那个mTOR1上游的信号级联刺激自噬。Rottlerin 通过活化caspase 3诱导细胞凋亡。 |
| IC50和靶点: | [{name:"PKCδ:3 μM (IC50, Porcine spleen)"},{name: "PKCα:30 μM (IC50, baculovirus-infected Sf9 insect cells)"},{name: "PKCγ:40 μM (IC50, baculovirus-infected Sf9 insect cells)"},{name: "PKCβ:42 μM (IC50, baculovirus-infected Sf9 insect cells)"},{name: "PKCη:82 μM (IC50, baculovirus-infected Sf9 insect cells)"},{name: "PKCζ:100 μM (IC50, baculovirus-infected Sf9 insect cells)"},{name: "PKCε:100 μM (IC50, baculovirus-infected Sf9 insect cells)"},{name: "CaM kinase III:5.3 μM (IC50, EF-2 kinase activity in cytosol of murine pancreas)"},{name: "CKII:30 μM (IC50, holoenzyme expressed in E.coli)"},{name: "PKA:78 μM (IC50, catalytic subunit from porcine heart)'}, 'HIV-1'] |
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Zhang, D., Anantharam, V., Kanthasamy, A., et al.Neuroprotective effect of protein kinase Cδ inhibitor rottlerin in cell culture and animal models of Parkinson's diseaseJ. Pharmacol. Exp. Ther.322(3),913-922(2007)
