Decursin
Cat. No.：YN310315
CAS No. ：5928-25-6
| 产品名称: | Decursin |
| CAS No.: | 5928-25-6 |
| Chemical Name: | 3-methyl-2-butenoic acid, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester |
| Synonyms: | 紫花前胡素; (+) |
| 分子量: | 328.36 |
| 分子式: | C₁₉H₂₀O₅ |
| SMILES: | C/C(C)=C\C(O[C@H](C(C)(C)O1)CC2=C1C=C(O3)C(C=CC3=O)=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Decursin ((+)-Decursin) 是一种细胞毒性剂，是一种来自Angelica gigas根的有效蛋白激酶 C (protein kinase C) 激活剂。Decursin 通过下调 CXCR7 表达来抑制胃癌中的肿瘤生长，迁移和侵袭。Decursin 通过 Hippo/YAP 信号通路抑制 HepG2 细胞的生长。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Kim, B.S., Seo, H., Kim, H.-J., et al.Decursin from Angelica gigas nakai inhibits B16F10 melanoma growth through induction of apoptosisJ. Med. Food.18(10),1121-1127(2015)
Kim, K.-J., Yeon, J.-T., Choi, S.-W., et al.Decursin inhibits osteoclastogenesis by downregulating NFATc1 and blocking fusion of pre-osteoclastsBone81,208-216(2015)
Lee, J.-K., Jeong, J.W., Jang, T., et al.Decursin attenuates kainic acid-induced seizures in miceNeuroreport25(16),1243-1249(2014)
Yang, Y., Yang, K., Li, Y., et al.Decursin inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2Mol. Cell. Endocrinol.378(1-2),46-52(2013)
Choi, Y.J., Kim, D.H., Kim, S.J., et al.Decursin attenuates hepatic fibrogenesis through interrupting TGF-beta-mediated NAD(P)H oxidase activation and Smad signaling in vivo and in vitroLife Sci.108(2),94-103(2014)
