Ingenol
Cat. No.：YN310349
| 产品名称: | Ingenol |
| CAS No.: | 30220-46-3 |
| Chemical Name: | (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one |
| Synonyms: | 巨大戟醇; (-) |
| 分子量: | 348.43 |
| 分子式: | C₂₀H₂₈O₅ |
| SMILES: | O[C@@]([C@@H](C(CO)=C[C@@]1([H])[C@H](C2(C)C)[C@H]2C3)O)([C@H]4O)[C@]([C@@H]3C)(C=C4C)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ingenol 是一种PKC激活剂，Ki值为 30 μM，具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"PKC:30 μM (Ki)"}] |
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| Solvent & Solubility: |
Wender, P.A., Koehler, K.F., Sharkey, N.A., et al.Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogsProc. Natl. Acad. Sci. USA83(12),4214-4218(1986)
Hasler, C.M., Acs, G., and Blumberg, P.M.Specific binding to protein kinase C by ingenol and its induction of biological responsesCancer Res.52(1),202-208(1992)
Vogg, G., Mattes, E., Rothenburger, J., et al.Tumor promoting diterpenes from Euphorbia leuconeura LPhytochemistry51(2),289-295(1999)
Nelson, T.J., and Alkon, D.L.Neuroprotective versus tumorigenic protein kinase C activatorsTrends Biochem. Sci.34(3),136-145(2009)
Lebwohl, M., Swanson, N., Anderson, L.L., et al.Ingenol mebutate gel for actinic keratosisN. Engl. J. Med.366(11),1010-1019(2012)
