K-252b
Cat. No.：YN310368
| 产品名称: | K-252b |
| CAS No.: | 99570-78-2 |
| Chemical Name: | (9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid |
| Synonyms: | K252b; K 252 b; K-252-b |
| 分子量: | 453.45 |
| 分子式: | C₂₆H₁₉N₃O₅ |
| SMILES: | C[C@@]([C@@]1(O)C(O)=O)(O[C@](N2C3=CC=CC=C43)([H])C1)N5C(C2=C4C6=C7CNC6=O)=C7C8=CC=CC=C58 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | K-252b 是从放线菌Nocardiopsis中分离得到的一种吲哚卡唑，是PKC的一个抑制剂。K-252b 不能自由通过细胞膜，因此常被用作胞外激酶的抑制剂。 |
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Yasuzawa, T., Iida, T., Yoshida, M., et al.The structures of the novel protein kinase C inhibitors K-252a, b, c and dJ. Antibiot. (Tokyo)39(8),1072-1078(1986)
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Teshima, R., Saito, Y., Ikebuchi, H., et al.Effect of an ectokinase inhibitor, K252b, on degranulation and Ca2+ signals of RBL-2H3 cells and human basophilsJ. Immunol.159(2),964-969(1997)
Thompson, A.F., and Levin, L.A.Neuronal differentiation by analogs of staurosporineNeurochem. Int.56(4),554-560(2010)
Kawamura, N., Kawamura, K., Manabe, M., et al.Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growthEndocrinology151(7),3006-3014(2010)
