KT5823
Cat. No.:YN310371
CAS No. :126643-37-6
产品名称: | KT5823 |
CAS No.: | 126643-37-6 |
Chemical Name: | 2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo[1,2,3-fg:3’,2’,1’-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester |
Synonyms: | 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylicacid, 2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-, methyl ester,(9S,10R,12R)-;9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazoc |
分子量: | 495.53 |
分子式: | C₂₉H₂₅N₃O₅ |
SMILES: | C[C@@]([C@@]1(OC)C(OC)=O)(O[C@](N2C3=C4C=CC=C3)([H])C1)N5C(C2=C4C6=C7CN(C)C6=O)=C7C8=C5C=CC=C8 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | KT5823 是一种选择性 cGMP 依赖性蛋白激酶 (PKG) 抑制剂,Ki值为 0.23 μM,KT5823 也可以抑制PKA和PKC,Ki值分别为 10 μM 和 4 μM。_x000D_ KT5823 是一种 staurosporine 星形孢菌素相关的蛋白激酶抑制剂,在甲状腺细胞中增加甲状腺刺激激素诱导的 (Na+/I-symporter) NIS 表达和碘离子摄取。_x000D_ KT5823 引起细胞凋亡 (apoptotic) DNA 片段化水平的增加。 |
IC50和靶点: | [{name:"PKA:10 μM (Ki)"},{name: "PKC:4 μM (Ki)"}] |
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Hidaka, H., and Kobayashi, R.Pharmacology of protein kinase inhibitorsAnnu. Rev. Pharmacol. Toxicol.32,377-397(1992)
Burkhardt, M., Glazova, M., Gambaryan, S., et al.KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cellsJ. Biol. Chem.275(43),33536-33541(2000)