LDN-193189 dihydrochloride
Cat. No.：YN460033
| 产品名称: | LDN-193189 dihydrochloride |
| CAS No.: | 1435934-00-1 |
| Chemical Name: | 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline, dihydrochloride |
| Synonyms: | DM-3189 dihydrochloride |
| 分子量: | 479.4039 |
| 分子式: | C25H22N6 • 2HCl |
| SMILES: | N1(C2=CC=C(C(C=N3)=CN4C3=C(C5=CC=NC6=C5C=CC=C6)C=N4)C=C2)CCNCC1.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LDN-193189 (dihydrochloride) 是一种有效的选择性BMP I型受体抑制剂。LDN-193189 有效抑制 BMP I 型受体ALK2和ALK3的转录活性，IC50值分别为 5 nM 和 30 nM。LDN-193189 可用于骨形态发生蛋白信号传导的研究，例如进行性骨化纤维发育不良。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Cuny, G.D., Yu, P.B., Laha, J.K., et al.Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitorsBioorg. Med. Chem. Lett.18(15),4388-4392(2008)
Sanvitale, C.E., Kerr, G., Chaikuad, A., et al.A new class of small molecule inhibitor of BMP signalingPLoS One8(4),62721(2013)
Yu, P.B., Deng, D.Y., Lai, C.S., et al.BMP type I receptor inhibition reduces heterotopic ossificationNat. Med.14(12),1363-1369(2008)
Lee, Y.C., Cheng, C.J., Bilen, M.A., et al.BMP4 promotes prostate tumor growth in bone through osteogenesisCancer Res.71(15),5194-5203(2011)
