HMN-214
Cat. No.：YN290170
CAS No. ：173529-46-9
| 产品名称: | HMN-214 |
| CAS No.: | 173529-46-9 |
| Chemical Name: | N-[(4-methoxyphenyl)sulfonyl]-N-[2-[(1E)-2-(1-oxido-4-pyridinyl)ethenyl]phenyl]-acetamide |
| Synonyms: | IVX-214 |
| 分子量: | 424.47 |
| 分子式: | C₂₂H₂₀N₂O₅S |
| SMILES: | CC(N(C1=C(C=CC=C1)/C=C/C2=CC=N(C=C2)=O)S(C3=CC=C(C=C3)OC)(=O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HMN-214 是一种可口服的 HMN-176 前体药物，为plk1抑制剂，具有抗肿瘤活性。 |
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Takagi, M., Honmura, T., Watanabe, S., et al.In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176Invest. New Drugs21(4),387-399(2003)
Tanaka, H., Ohshima, N., Ikenoya, M., et al.HMN-176, an active metabolite of the synthetic antitumor agent HMN-214, restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-YCancer Res.63(20),6942-6947(2003)
