Poloxin
Cat. No.：YN290174
| 产品名称: | Poloxin |
| CAS No.: | 321688-88-4 |
| Chemical Name: | 1-[O-(2-methylbenzoyl)oxime]2-methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione |
| Synonyms: | |
| 分子量: | 297.35 |
| 分子式: | C₁₈H₁₉NO₃ |
| SMILES: | O=C(C(C(C)C)=C/1)C=C(C)C1=N/OC(C2=CC=CC=C2C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Poloxin 是一种Polo-like Kinase 1 (PLK1)的 ATP 非竞争性抑制剂，靶作用于 polo-box 结构域，IC50值约为 4.8 μM。 |
| IC50和靶点: | [{name:"PLK1 PBD:4.8 μM (IC50)"},{name: "PLK2 PBD:18.7 μM (IC50)"},{name: "PLK3 PBD:53.9 μM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Reindl, W., Yuan, J., Krämer, A., et al.Inhibition of polo-like kinase 1 by blocking polo-box domain-dependent protein-protein interactionsChem. Biol.15(5),459-466(2008)
Yuan, J., Sanhaji, M., Krämer, A., et al.Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivoAm. J. Pathol.179(4),2091-2099(2011)
