MLN0905
Cat. No.：YN290330
CAS No. ：1228960-69-7
| 产品名称: | MLN0905 |
| CAS No.: | 1228960-69-7 |
| Chemical Name: | 2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)-6H-pyrimido[5,4-d][1]benzazepine-6-thione |
| Synonyms: | PLK1 Inhibitor |
| 分子量: | 486.56 |
| 分子式: | C₂₄H₂₅F₃N₆S |
| SMILES: | CC1=NC=C(CCCN(C)C)C=C1NC2=NC(C(C=CC(C(F)(F)F)=C3)=C3NC(C4)=S)=C4C=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MLN0905 是一种有效的PLK1抑制剂，IC50值为 2 nM。 |
| IC50和靶点: | [{name:"PLK1:2 nM (IC50)"}] |
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| Solvent & Solubility: |
Duffey, M.O., Vos, T.J., Adams, R., et al.Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of polo-like kinase 1 (MLN0905)J. Med. Chem.55(1),197-208(2012)
Shi, J.Q., Lasky, K., Shinde, V., et al.MLN0905, a small-molecule PLK1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphomaMol. Cancer Ther.11(9),2045-2053(2012)
