Centrinone
Cat. No.：YN290438
| 产品名称: | Centrinone |
| CAS No.: | 1798871-30-3 |
| Chemical Name: | 2-[[2-fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine |
| Synonyms: | LCR-263 |
| 分子量: | 633.65 |
| 分子式: | C₂₆H₂₅F₂N₇O₆S₂ |
| SMILES: | FC(C([N+]([O-])=O)=CC=C1)=C1CS(C2=CC(F)=C(SC3=NC(NC4=NNC(C)=C4)=C(OC)C(N5CCOCC5)=N3)C=C2)(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Centrinone (LCR-263) 是选择性，可逆的PLK4抑制剂，Ki值为 0.16 nM。 |
| IC50和靶点: | [{name:"PLK4:0.16 nM (Ki)"},{name: "PLK4 (G95L):68.57 nM (Ki)"},{name: "Aurora A:171 nM (Ki)"},{name: "Aurora B:436.76 nM (Ki)"}] |
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| Solvent & Solubility: |
Wong, Y.L., Anzola, J.V., Davis, R.L., et al.Reversible centriole depletion with an inhibitor of polo-like kinase 4Science348(6239),1155-1160(2015)
