Centrinone-B
Cat. No.：YN290439
CAS No. ：1798871-31-4
| 产品名称: | Centrinone-B |
| CAS No.: | 1798871-31-4 |
| Chemical Name: | 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine; |
| Synonyms: | LCR-323 |
| 分子量: | 631.67 |
| 分子式: | C₂₇H₂₇F₂N₇O₅S₂ |
| SMILES: | FC(C([N+]([O-])=O)=CC=C1)=C1CS(C2=CC(F)=C(SC3=NC(NC4=NNC(C)=C4)=C(OC)C(N5CCCCC5)=N3)C=C2)(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Centrinone-B (LCR-323) 是一种有效的，高度选择性的PLK4抑制剂，Ki值为 0.59 nM。 |
| IC50和靶点: | [{name:"PLK4:0.59 nM (Ki)"},{name: "PLK4 (G95L):497.53 nM (Ki)"},{name: "Aurora A:1239 nM (Ki)"},{name: "Aurora B:5597.14 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Wong, et al.: Science, 348, 1155 (2015)
