BMS-687453
Cat. No.：YN290071
CAS No. ：1000998-59-3
| 产品名称: | BMS-687453 |
| CAS No.: | 1000998-59-3 |
| Chemical Name: | N-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-N-(methoxycarbonyl)-glycine |
| Synonyms: | (S)-4-(6-chloro-4-cyclopropyl-2-oxo-3-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)benzonitrile;2-[[3-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-methoxycarbonylamino]acetic acid;BMS 687453;BMS-687453;7HA;AGN-PC-014V8R; |
| 分子量: | 444.86 |
| 分子式: | C₂₂H₂₁ClN₂O₆ |
| SMILES: | ClC(C=C1)=CC=C1C2=NC(COC3=CC=CC(CN(C(OC)=O)CC(O)=O)=C3)=C(C)O2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-687453 是一种有效的，选择性的PPARα激动剂，对人PPARα的EC50和IC50分别为 10 nM 和 260 nM；较弱地抑制 PPARγ 的活性，EC50和IC50值分别为 4100 nM 和 >15000 nM。 |
| IC50和靶点: | [{name:"PPARα:260 nM (IC50, Human PPARα)"}] |
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| Solvent & Solubility: |
Li, J., Kennedy, L.J., Shi, Y., et al.Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor α selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453)J. Med. Chem.53(7),2854-2864(2010)
Mukherjee, R., Locke, K.T., Miao, B., et al.Novel peroxisome proliferator-activated receptor α agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonistJ. Pharmacol. Exp. Ther.327(3),716-726(2008)
