Leriglitazone
Cat. No.：YN290158
| 产品名称: | Leriglitazone |
| CAS No.: | 146062-44-4 |
| Chemical Name: | 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione |
| Synonyms: | Hydroxypioglitazone |
| 分子量: | 372.44 |
| 分子式: | C₁₉H₂₀N₂O₄S |
| SMILES: | O=C(N1)SC(CC2=CC=C(OCCC3=NC=C(C(O)C)C=C3)C=C2)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Leriglitazone (Hydroxypioglitazone)，吡格列酮的代谢产物。_x000D_ Leriglitazone (Hydroxypioglitazone) 是PPARγ激动剂，通过稳定 PPARγ (AF-2) 共激活剂结合表面和增强共激活剂结合能力，提供高转录效力。_x000D_ Leriglitazone（Hydroxypioglitazone) 与 PPARγC (LBD) 结合，其Ki值为 1.2 μM，诱导 PPARγ (LBD) 转录效率，EC50为 680 nM。 |
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Mosure, S.A., Shang, J., Eberhardt, J., et al.Structural basis of altered potency and efficacy displayed by a major in vivo metabolite of the antidiabetic PPARγ drug pioglitazoneJ. Med. Chem.62(4),2008-2023(2019)
Jaakkola, T., Backman, J.T., Neuvonen, M., et al.Effect of rifampicin on the pharmacokinetics of pioglitazoneBr. J. Clin. Pharmacol.61(1),70-78(2005)
