T0070907
Cat. No.：YN290243
CAS No. ：313516-66-4
| 产品名称: | T0070907 |
| CAS No.: | 313516-66-4 |
| Chemical Name: | 2-chloro-5-nitro-N-4-pyridinyl-benzamide |
| Synonyms: | T-0070907;T 0070907 |
| 分子量: | 277.66 |
| 分子式: | C₁₂H₈ClN₃O₃ |
| SMILES: | ClC1=C(C=C(C=C1)[N+]([O-])=O)C(NC2=CC=NC=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | T0070907是有效的PPARγ拮抗剂，Ki值为1 nM。 |
| IC50和靶点: | [{name:"PPARγ:1 nM (Ki)"},{name: "PPARδ:1.8 μM (Ki)"},{name: "PPARα:0.85 μM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Willson, T.M., Cobb, J.E., Cowan, D.J., et al.The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinedionesJ. Med. Chem.39(3),665-668(1996)
Cantello, B.C.C., Cawthorne, M.A., Cottam, G.P., et al.[[ω-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agentsJ. Med. Chem.37,3977-3985(1994)
Davies, S.S., Pontsler, A.V., Marathe, G.K., et al.Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor γ ligands and agonistsJ. Biol. Chem.276(19),16015-16023(2001)
Maxey, K.M., Hessler, E., MacDonald, J., et al.The nature and composition of 15-deoxy-Δ12,14-PGJ2Prostaglandins Other Lipid Mediat.62(1),15-21(2000)
Wright, H.M., Clish, C.B., Mikami, T., et al.A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiationJ. Biol. Chem.275(3),1873-1877(2000)
Lee, G., Elwood, F., McNally, J., et al.T0070907, a selective ligand for peroxisome proliferator-activated receptor γ, functions as an antagonist of biochemical and cellular activitiesJ. Biol. Chem.277(22),19649-19657(2002)
