GW0742
Cat. No.：YN290301
CAS No. ：317318-84-6
| 产品名称: | GW0742 |
| CAS No.: | 317318-84-6 |
| Chemical Name: | 2-[4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]-acetic acid |
| Synonyms: | GW610742 |
| 分子量: | 471.49 |
| 分子式: | C₂₁H₁₇F₄NO₃S₂ |
| SMILES: | O=C(O)COC1=CC=C(SCC2=C(C)N=C(C3=CC=C(C(F)(F)F)C(F)=C3)S2)C=C1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GW0742 是一种有效的PPARβ和PPARδ激动剂，在蛋白质结合实验中，对人PPARδ的IC50值为 1 nM；同时对人PPARδ，PPARα 和 PPARγ 的EC50值分别为 1 nM，1.1 μM 和 2 μM。 |
| IC50和靶点: | [{name:"PPARδ:1 nM (EC50)"},{name: "PPARα:1.1 μM (EC50)"},{name: "PPARγ:2 μM (EC50)"}] |
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| Solvent & Solubility: |
Sznaidman, M.L., Haffner, C.D., Maloney, P.R., et al.Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)-synthesis and biological activityBioorg. Med. Chem. Lett.13(9),1517-1521(2003)
Smith, S.A., Monteith, G.R., Robinson, J.A., et al.Effect of the peroxisome proliferator-activated receptor β activator GW0742 in rat cultured cerebellar granule neuronsJ. Neurosci. Res.77(2),240-249(2004)
