GSK3787
Cat. No.：YN290353
| 产品名称: | GSK3787 |
| CAS No.: | 188591-46-0 |
| Chemical Name: | 4-chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]-benzamide |
| Synonyms: | GSK3787，GSK-3787，GSK 3787 |
| 分子量: | 392.78 |
| 分子式: | C₁₅H₁₂ClF₃N₂O₃S |
| SMILES: | O=C(NCCS(=O)(C1=NC=C(C(F)(F)F)C=C1)=O)C2=CC=C(Cl)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK3787 是一种选择性和不可逆的过氧化物酶体增殖物激活受体 δ (PPARδ) 拮抗剂，pIC50为 6.6。 |
| IC50和靶点: | [{name:"PPARδ:6.6 nM (pIC50)"}] |
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| Solvent & Solubility: |
Michalik, L., Desvergne, B., and Wahli, W.Peroxisome-proliferator-activated receptors and cancers: Complex storiesNat. Rev. Cancer4(1),61-70(2004)
Girroir, E.E., Hollingshead, H.E., Billin, A.N., et al.Peroxisome proliferator-activated receptor-ß/δ (PPAR ß/δ) ligands inhibit growth of UACC903 and MCF7 human cancer cell linesToxicology243(1-2),236-243(2008)
Peters, J.M., Foreman, J.E., and Gonzalez, F.J.Dissecting the role of peroxisome proliferator-activated receptor-ß/δ (PPARß/δ) in colon, breast, and lung carcinogenesisCancer Metastasis Rev.30(3-4),619-640(2011)
Elikkottil, J., Kohli, D.R., and Gupta, K.Antitumor activity of a PPARδ antagonistCancer Biol. Ther.8(13),1262-1264(2009)
Shearer, B.G., Wiethe, R.W., Ashe, A., et al.Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor δ (PPARδ) antagonistJ. Med. Chem.53(4),1857-1861(2010)
Palkar, P.S., Borland, M.G., Naruhn, S., et al.Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-β/δ antagonist GSK3787Mol. Pharmacol.78(3),419-430(2010)
