Balaglitazone
Cat. No.：YN290381
CAS No. ：199113-98-9
| 产品名称: | Balaglitazone |
| CAS No.: | 199113-98-9 |
| Chemical Name: | 5-[[4-[(3,4-dihydro-3-methyl-4-oxo-2-quinazolinyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione |
| Synonyms: | DRF 2593; NN 2344 |
| 分子量: | 395.43 |
| 分子式: | C₂₀H₁₇N₃O₄S |
| SMILES: | O=C(N1)SC(CC2=CC=C(OCC(N3C)=NC4=C(C=CC=C4)C3=O)C=C2)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Balaglitazone 是一种选择性的PPARγ部分激动剂，对人PPARγ的EC50值为 1.351 μM。 |
| IC50和靶点: | [{name:"PPARγ:351 nM (EC50, Human PPARγ)"}] |
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Larsen, P.J., Lykkegaard, K., Larsen, L.K., et al.Dissociation of antihyperglycaemic and adverse effects of partial perioxisome proliferator-activated receptor (PPAR-γ) agonist balaglitazoneEur. J. Pharmacol.596(1-3),173-179(2008)
Henriksen, K., Byrjalsen, I., Nielsen, R.H., et al.A comparison of glycemic control, water retention, and musculoskeletal effects of balaglitazone and pioglitazone in diet-induced obese ratsEur. J. Pharmacol.616(1-3),340-345(2009)
Yousefi, B., Azimi, A., Majidinia, M., et al.Balaglitazone reverses P-glycoprotein-mediated multidrug resistance via upregulation of PTEN in a PPARγ-dependent manner in leukemia cellsTumour Biol.39(10),(2017)
