GW9662
Cat. No.：YN290399
CAS No. ：22978-25-2
| 产品名称: | GW9662 |
| CAS No.: | 22978-25-2 |
| Chemical Name: | 2-chloro-5-nitrobenzanilide |
| Synonyms: | TIMTEC-BB SBB006523 |
| 分子量: | 276.68 |
| 分子式: | C₁₃H₉ClN₂O₃ |
| SMILES: | O=C(NC1=CC=CC=C1)C2=CC([N+]([O-])=O)=CC=C2Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GW9662是有效，选择性的PPARγ拮抗剂，IC50值为3.3 nM，比PPARα和PPARδ的选择性高10倍和1000倍。 |
| IC50和靶点: | [{name:"PPARγ:3.3 nM (IC50)"},{name: "PPARα:32 nM (IC50)"},{name: "PPARδ:2000 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Willson, T.M., Cobb, J.E., Cowan, D.J., et al.The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinedionesJ. Med. Chem.39(3),665-668(1996)
Maxey, K.M., Hessler, E., MacDonald, J., et al.The nature and composition of 15-deoxy-Δ12,14-PGJ2Prostaglandins Other Lipid Mediat.62(1),15-21(2000)
Wright, H.M., Clish, C.B., Mikami, T., et al.A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiationJ. Biol. Chem.275(3),1873-1877(2000)
Lehmann, J.M., Moore, L.B., Smith-Oliver, T.A., et al.An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)J. Biol. Chem.270(22),12953-12956(1995)
Cantello, B.C.C., Cawthorne, M.A., Cottam, G.P., et al.[[ω-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agentsJ. Med. Chem.37,3977-3985(1994)
Davies, S.S., Pontsler, A.V., Marathe, G.K., et al.Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor γ ligands and agonistsJ. Biol. Chem.276(19),16015-16023(2001)
Bendixen, A.C., Shevde, N.K., Dienger, K.M., et al.IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor γ1Proc. Natl. Acad. Sci. USA98,2443-2448(2001)
