Elafibranor
Cat. No.：YN290405
CAS No. ：923978-27-2
| 产品名称: | Elafibranor |
| CAS No.: | 923978-27-2 |
| Chemical Name: | 2-[2,6-dimethyl-4-[(1E)-3-[4-(methylthio)phenyl]-3-oxo-1-propen-1-yl]phenoxy]-2-methyl-propanoic acid |
| Synonyms: | GFT505 |
| 分子量: | 384.49 |
| 分子式: | C₂₂H₂₄O₄S |
| SMILES: | CC(C)(OC1=C(C)C=C(/C=C/C(C2=CC=C(SC)C=C2)=O)C=C1C)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Elafibranor (GFT505) 是PPARα/δ的激动剂，EC50分别为 45 和 175 nM。 |
| IC50和靶点: | [{name:"PPAR-α:45 nM (EC50)"},{name: "PPAR-δ:175 nM (EC50)"}] |
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| Solvent & Solubility: |
Colin, S., Briand, O., Touche, V., et al.Activation of intestinal peroxisome proliferator-activated receptor-α increases high-density lipoprotein productionEur. Heart J.34(32),2566-2574(2013)
Staels, B., Rubenstrunk, A., Noel, B., et al.Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitisHepatology58(6),1941-1952(2013)
