Tesaglitazar
Cat. No.：YN290418
CAS No. ：251565-85-2
| 产品名称: | Tesaglitazar |
| CAS No.: | 251565-85-2 |
| Chemical Name: | αS-ethoxy-4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]-benzenepropanoic acid |
| Synonyms: | Tesaglitazar; AR-H-039242XX; AZ-242; AZ242; AZ 242; ARH-039242XX; Galida. |
| 分子量: | 408.47 |
| 分子式: | C₂₀H₂₄O₇S |
| SMILES: | O=C(O)[C@@H](OCC)CC1=CC=C(OCCC2=CC=C(OS(=O)(C)=O)C=C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tesaglitazar 是一种过氧物酶体 PPAR alpha/gamma 受体的双重激动剂，对 PPARγ 的作用比 PPARα 强，对大鼠和人类 PPARα 作用的EC50分别为 13.4 μM 和 3.6 μM，对大鼠和人类 PPARγ 作用的EC50为 0.2 μM。Tesaglitazar 在大鼠皮下组织中，诱导间质间充质细胞 DNA 合成和纤维肉瘤形成。 |
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Cronet, P., Petersen, J.F.W., Folmer, R., et al.Structure of the PPARα and -γ ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR familyStructure9(8),699-706(2001)
Wallenius, K., Kjellstedt, A., Thalén, P., et al.The PPARα/γ agonist, tesaglitazar, improves insulin mediated switching of tissue glucose and free fatty acid utilization in vivo in the obese Zucker ratPPAR Res.,305347(2013)
Wilding, J.P.H., Gause-Nilsson, I., Persson, A., et al.Tesaglitazar, as add-on therapy to sulphonylurea, dose-dependently improves glucose and lipid abnormalities in patients with type 2 diabetesDiab. Vasc. Dis. Res.4(3),194-203(2007)
