DG172 dihydrochloride
Cat. No.：YN290464
CAS No. ：1361504-77-9
| 产品名称: | DG172 dihydrochloride |
| CAS No.: | 1361504-77-9 |
| Chemical Name: | 2-bromo-αZ-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]-benzeneacetonitrile, dihydrochloride |
| Synonyms: | DG172 (dihydrochloride),DG-172 dihydrochloride |
| 分子量: | 455.22 |
| 分子式: | C₂₀H₂₂BrCl₂N₃ |
| SMILES: | BrC(C=CC=C1)=C1/C(C#N)=C/C(C=C2)=CC=C2N3CCN(C)CC3.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DG172 dihydrochloride 是一种选择性的PPARβ/δ拮抗剂，IC50值为 27 nM。 |
| IC50和靶点: | [{name:"PPARβ/δ:27 nM (IC50)"}] |
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Lieber, S., Scheer, F., Meissner, W., et al.(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): An orally bioavailable PPARβ/δ-selective ligand with inverse agonistic propertiesJ. Med. Chem.55(6),2858-2868(2012)
Lieber, S., Scheer, F., Finkernagel, F., et al.The inverse agonist DG172 triggers a PPARβ/δ-independent myeloid lineage shift and promotes GM-CSF/IL-4-induced dendritic cell differentiationMol. Pharmacol.87(2),162-173(2015)
Adhikary, T., Brandt, D.T., Kaddatz, K., et al.Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasionOncogene32(44),5241-5252(2013)
