Bezafibrate
Cat. No.：YN290507
| 产品名称: | Bezafibrate |
| CAS No.: | 41859-67-0 |
| Chemical Name: | 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl-propanoic acid |
| Synonyms: | 苯扎贝特; BM15075 |
| 分子量: | 361.82 |
| 分子式: | C₁₉H₂₀ClNO₄ |
| SMILES: | CC(C)(OC1=CC=C(CCNC(C2=CC=C(Cl)C=C2)=O)C=C1)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bezafibrate 是PPAR的激动剂，对人和鼠PPARα，PPARγ和PPARδ的EC50分别为 50 μM，60 μM，20 μM 和 90 μM，55 μM，110 μM；Bezafibrate 是一种降血脂剂。 |
| IC50和靶点: | [{name:"hPPARδ:20 μM (EC50)"},{name: "hPPARα:50 μM (EC50)"},{name: "hPPARγ:60 μM (EC50)"}] |
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Willson, T.M., Brown, P.J., Sternbach, D.D., et al.The PPARs: From orphan receptors to drug discoveryJ. Med. Chem.43(4),527-550(2000)
Rogue, A., Anthérieu, S., Vluggens, A., et al.PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cellsToxicol. Appl. Pharmacol.276(1),73-81(2014)
Matsui, H., Okumura, K., Kawakami, K., et al.Improved insulin sensitivity by bezafibrate in rats: Relationship to fatty acid composition of skeletal-muscle triglyceridesDiabetes46(3),348-353(1997)
