5-Ethynyl-2'-deoxyuridine
Cat. No.：YN430087
CAS No. ：61135-33-9
规格
价格(RMB)
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| 产品名称: | 5-Ethynyl-2'-deoxyuridine |
| CAS No.: | 61135-33-9 |
| Chemical Name: | 2'-deoxy-5-ethynyl-uridine |
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| 分子量: | 252.22 |
| 分子式: | C₁₁H₁₂N₂O₅ |
| SMILES: | O=C1NC(C(C#C)=CN1[C@H]2C[C@@H]([C@H](O2)CO)O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 5-Ethynyl-2'-deoxyuridine (EdU) 是一种胸腺嘧啶核苷类似物，在细胞增殖时能够插入正在复制的 DNA 分子中， EdU 与染料的共轭反应可以进行高效快速的细胞增殖检测分析。5-Ethynyl-2'-deoxyuridine 是一种 PROTAC linker，属于 alkyl chain 类。可用于合成 PROTAC 分子。 |
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Buck, S.B., Bradford, J., Gee, K.R., et al.Detection of S-phase cell cycle progression using 5-ethynyl-2'-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2'-deoxyuridine antibodiesBiotechniques44,924-929(2008)
Cavanagh, B.L., Walker, T., Norazit, A., et al.Thymidine analogues for tracking DNA synthesisMolecules16,7980-7993(2011)
Meneni, S., Ott, I., Sergeant, C.D., et al.5-Alkynyl-2'-deoxyuridines: Chromatography-free synthesis and cytotoxicity evaluation against human breast cancer cellsBioorg. Med. Chem.15(8),3082-3088(2007)
