Alkynyl Palmitic Acid
Cat. No.:YN430418
产品名称: | Alkynyl Palmitic Acid |
CAS No.: | 99208-90-9 |
Chemical Name: | 15-hexadecynoic acid |
Synonyms: | |
分子量: | 252.39 |
分子式: | C₁₆H₂₈O₂ |
SMILES: | C#CCCCCCCCCCCCCCC(O)=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Alkynyl Palmitic Acid 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。 |
IC50和靶点: | |
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In Vivo: | |
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Aicart-Ramos, C., Valero, R.A., and Rodriguez-Crespo, I.Protein palmitoylation and subcellular traffickingBiochim. Biophys. Acta1808,2981-2994(2011)
Kolb, H.C., and Sharpless, K.B.The growing impact of click chemistry on drug discoveryDrug Discov. Today8(24),1128-1137(2003)
Lutz, J.-F., and Zarafshani, Z.Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistryAdv. Drug Deliv. Rev.60(9),958-970(2008)
Martin, B.R., and Cravatt, B.F.Large-scale profiling of protein palmitoylation in mammalian cellsNat. Methods6(2),135-138(2009)
Yap, M.C., Kostiuk, M.A., Martin, D.D.O., et al.Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistryJ. Lipid Res.51(6),1566-1580(2010)
Jiang, H., Khan, S., Wang, Y., et al.SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysineNature496,110-113(2013)