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Alkynyl Palmitic Acid

Cat. No.:YN430418

  • CAS No. :99208-90-9

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    • 产品名称: Alkynyl Palmitic Acid
      CAS No.: 99208-90-9
      Chemical Name: 15-hexadecynoic acid
      Synonyms:
      分子量:252.39
      分子式:C₁₆H₂₈O₂
      SMILES:C#CCCCCCCCCCCCCCC(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Alkynyl Palmitic Acid 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Aicart-Ramos, C., Valero, R.A., and Rodriguez-Crespo, I.Protein palmitoylation and subcellular traffickingBiochim. Biophys. Acta1808,2981-2994(2011)

      Kolb, H.C., and Sharpless, K.B.The growing impact of click chemistry on drug discoveryDrug Discov. Today8(24),1128-1137(2003)

      Lutz, J.-F., and Zarafshani, Z.Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistryAdv. Drug Deliv. Rev.60(9),958-970(2008)

      Martin, B.R., and Cravatt, B.F.Large-scale profiling of protein palmitoylation in mammalian cellsNat. Methods6(2),135-138(2009)

      Yap, M.C., Kostiuk, M.A., Martin, D.D.O., et al.Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistryJ. Lipid Res.51(6),1566-1580(2010)

      Jiang, H., Khan, S., Wang, Y., et al.SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysineNature496,110-113(2013)

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