dBET1
Cat. No.：YN430007
CAS No. ：1799711-21-9
规格
价格(RMB)
库存
| 产品名称: | dBET1 |
| CAS No.: | 1799711-21-9 |
| Chemical Name: | (6S)-4-(4-chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Synonyms: | |
| 分子量: | 785.27 |
| 分子式: | C₃₈H₃₇ClN₈O₇S |
| SMILES: | O=C(NCCCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | dBET1 是基于PROTAC技术的有效的BRD4蛋白质降解物，其EC50值为 430 nM。dBET1 是一种由 BRD4 抑制剂 JQ1 (HY-13030) 与 NSC 527179 (HY-14658) 衍生物通过 linker 产生的 PROTAC，能够在低纳摩尔浓度下诱导 BRD4 降解。 |
| IC50和靶点: | [{name:"BRD4:430 nM (EC50)'}, 'Cereblon'] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Winter, G.E., Bucklet, D.L., Paulk, J., et al.Phthalimide conjugation as a strategy for in vivo target protein degradationSciencexpress,1-9(2015)
