MZ 1
Cat. No.：YN430032
CAS No. ：1797406-69-9
规格
价格(RMB)
库存
| 产品名称: | MZ 1 |
| CAS No.: | 1797406-69-9 |
| Chemical Name: | (4R)-N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide |
| Synonyms: | MZ-1;MZ 1 |
| 分子量: | 1002.64 |
| 分子式: | C₄₉H₆₀ClN₉O₈S₂ |
| SMILES: | CC1=C(C)SC2=C1C(C3=CC=C(Cl)C=C3)=N[C@@H](CC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@@H](O)C4)C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)=O)=O)=O)C7=NN=C(C)N27 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MZ 1 是一种PROTAC BRD4降解剂。MZ 1 强效迅速地诱导 BRD4 降解，选择性高于 BRD2 和 BRD3。对BRD4 BD1/2，BRD3 BD1/2 和 BRD2 BD1/2 的Kd分别为 382/120，119/115 和 307/228 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Zengerle, M., Chan, K.-H., and Ciulli, A.Selective small molecule induced degradation of the BET bromodomain protein BRD4ACS Chem. Biol.10(8),1770-1777(2015)
