VZ185
Cat. No.：YN430078
CAS No. ：2306193-61-1
规格
价格(RMB)
库存
| 产品名称: | VZ185 |
| CAS No.: | 2306193-61-1 |
| Chemical Name: | |
| Synonyms: | VZ185;VZ 185;(2S,4R)-N-(2-((5-(4-(2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine- |
| 分子量: | 995.21 |
| 分子式: | C₅₃H₆₇FN₈O₈S |
| SMILES: | O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3OCCCCCN5CCN(CC6=C(OC)C=C(C(C7=CC=NC=C87)=CN(C)C8=O)C=C6OC)CC5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VZ185 是高效，快速，选择性的BRD7/9 PROTAC降解剂，DC50分别为 4.5 和 1.8 nM。VZ185对 EOL-1 和 A-402 细胞具有细胞毒性，EC50分别为 3nM 和 40nM。 |
| IC50和靶点: | [{name:"BRD7:4.5 nM (DC50)"},{name: "BRD9:1.8 nM (DC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
