dBET57
Cat. No.：YN430098
CAS No. ：1883863-52-2
规格
价格(RMB)
库存
| 产品名称: | dBET57 |
| CAS No.: | 1883863-52-2 |
| Chemical Name: | (6S)-4-(4-chlorophenyl)-N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide |
| Synonyms: | dBET57,dBET 57,dBET-57 |
| 分子量: | 699.18 |
| 分子式: | C₃₄H₃₁ClN₈O₅S |
| SMILES: | O=C(NCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | dBET57 是一种有效选择性的BRD4BD1降解剂，基于PROTAC技术。dBET57 介导了 E3 泛素连接酶 CRL4CRBN的招募，对 BRD4BD1作用的DC50/5h值为 500 nM，对 BRD4BD2不起作用。 |
| IC50和靶点: | [{name:"BRD4 (BD1):500 nM (DC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Nowak, R.P., DeAngelo, S.L., Buckley, D., et al.Plasticity in binding confers selectivity in ligand-induced protein degradationNat. Chem. Biol.14(7),706-714(2018)
