PROTAC Mcl1 degrader-1
Cat. No.：YN430110
CAS No. ：2163793-38-0
规格
价格(RMB)
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| 产品名称: | PROTAC Mcl1 degrader-1 |
| CAS No.: | 2163793-38-0 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 909.84 |
| 分子式: | C₄₅H₄₅BrN₆O₈S |
| SMILES: | O=C(C1=CC=CC(NCCCCCCNC(CCCCC(NCCN2C(C3=C4C(C2=O)=CC=C(C4=CC=C3)SC5=CC=C(C=C5)Br)=O)=O)=O)=C1C6=O)N6C7CCC(NC7=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PROTAC Mcl1 degrader-1 (compound C3) 是一种靶向嵌合体的蛋白水解 (PROTAC)，是有效，选择性的Mcl-1抑制剂，IC50为 0.7 μM。PROTAC Mcl1 degrader-1 通过将具有微摩尔范围亲和力的 E3 连接酶脑 (CRBN) 结合配体 pomalidomide 引入 Mcl-1 抑制剂 S1-6 来诱导 Mcl-1 的泛素化和蛋白酶体降解。 |
| IC50和靶点: | [{name:"Mcl-1:0.78 μM (IC50)"},{name: "Bcl-2:0.54 μM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
