ACBI1
Cat. No.：YN430124
CAS No. ：2375564-55-7
规格
价格(RMB)
库存
| 产品名称: | ACBI1 |
| CAS No.: | 2375564-55-7 |
| Chemical Name: | (2S,4R)-N-(2-(2-(4-((4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide |
| Synonyms: | |
| 分子量: | 936.10 |
| 分子式: | C₄₉H₅₈FN₉O₇S |
| SMILES: | CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(C4(CC4)F)=O)=O)=O)C(OCCOC5=CC=C(CN6CCN(C7=CC(C8=C(O)C=CC=C8)=NN=C7N)CC6)C=C5)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ACBI1 是一种有效的，基于PROTAC技术的 BAF ATPase 亚基SMARCA2和SMARCA4降解剂，也是 PBAF 成员PBRM1的降解剂, 对 SMARCA2、SMARCA4 和 PBRM1 作用的DC50值分别为 6 nM、11 nM 和 32 nM。ACBI1 由一个 bromodomain 配体、linker 和 E3 泛素连接酶 VHL 构成，能诱导抗增殖作用和凋亡。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Farnaby, W., Koegl, M., Roy, M.J., et al.BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC designNat. Chem. Biol.15(7),672-680(2019)
Battistello, E., Hixon, K.A., Comstock, D.E., et al.Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustionMol. Cell.S1097-2765(23),00153-00153(2023)
