DT2216
Cat. No.：YN430171
CAS No. ：2365172-42-3
规格
价格(RMB)
库存
| 产品名称: | DT2216 |
| CAS No.: | 2365172-42-3 |
| Chemical Name: | (2S,4R)-1-((S)-2-(7-(4-((R)-3-((4-(N-(4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimet |
| Synonyms: | |
| 分子量: | 1542.36 |
| 分子式: | C₇₇H₉₆ClF₃N₁₀O₁₀S₄ |
| SMILES: | CC1(C)CCC(C2=CC=C(Cl)C=C2)=C(C1)CN3CCN(C4=CC=C(C(NS(=O)(C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@@H](CSC6=CC=CC=C6)CCN7CCN(C(CCCCCC(N[C@@H](C(C)(C)C)C(N8[C@@H](C[C@@H](O)C8)C(N[C@H](C9=CC=C(C%10=C(N=CS%10)C)C=C9)C)=O)=O)=O)=O)CC7)C=C5)=O)=O)C=C4)CC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DT2216 是一种PROTAC类的有效的，选择性的BCL-XL降解剂。DT2216 通过募集 Von Hippel-Lindau (VHL) E3 泛素连接酶来降解 BCR-ABL 蛋白。DT2216 可以抑制各种 BCL-XL 依赖性白血病和癌细胞，但对血小板的毒性要小得多。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Khan, S., Zhang, X., Lv, D., et al.A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activityNat. Med.25(12),1938-1947(2019)
