ARV-825
Cat. No.：YN430359
CAS No. ：1818885-28-7
规格
价格(RMB)
库存
| 产品名称: | ARV-825 |
| CAS No.: | 1818885-28-7 |
| Chemical Name: | 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide |
| Synonyms: | |
| 分子量: | 923.43 |
| 分子式: | C₄₆H₄₇ClN₈O₉S |
| SMILES: | CC1=NN=C2N1C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N[C@H]2CC(NC5=CC=C(OCCOCCOCCOCCNC6=C(C(N(C7CCC(NC7=O)=O)C8=O)=O)C8=CC=C6)C=C5)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ARV-825 是一种 PROTAC 类的BRD4降解剂。ARV-825 对 BRD4 的 BD1 和 BD2 结构域具有高亲和力，Kd值分别为 90 和 28 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Lu, J., Qian, Y., Altieri, M., et al.Hijacking the E3 ubiquitin ligase cereblon to efficiently target BRD4Chem. Biol.22(6),755-763(2015)
Abruzzese, M.P., Bilotta, M.T., Fionda, C., et al.Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplayJ. Hematol. Oncol.9(1),134(2016)
