VO-Ohpic trihydrate
Cat. No.：YN420149
CAS No. ：476310-60-8
规格
价格(RMB)
库存
| 产品名称: | VO-Ohpic trihydrate |
| CAS No.: | 476310-60-8 |
| Chemical Name: | (OC-6-45)-aqua(3-hydroxy-2-pyridinecarboxylato-κN1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxo-vanadate(1-), hydrogen, trihydrate |
| Synonyms: | VO-Ohpic |
| 分子量: | 415.20 |
| 分子式: | C₁₂H₁₆N₂O₁₁V |
| SMILES: | O[V+2]([N]1=CC=CC(O)=C1C2=O)([O-]2)([O-]C3=CC=CN=C3C4=O)([O-]4)=O.[H+].[3H2O] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VO-Ohpic trihydrate 是一种高效的PTEN抑制剂，IC50为 46±10 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Rosivatz, E., Matthews, J.G., McDonald, N.Q., et al.A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN)ACS Chem. Biol.1(12),780-790(2006)
Mak, L.H., Vilar, R., and Woscholski, R.Characterisation of the PTEN inhibitor VO-OHpicJ. Chem. Biol.3(4),157-163(2010)
Zu, L., Shen, Z., Wesley, J., et al.PTEN inhibitors cause a negative inotropic and chronotropic effect in miceEur. J. Pharmacol.650(1),298-302(2011)
Sharma, M.D., Shinde, R., McGaha, T.L., et al.The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironmentSci. Adv.1(10),e1500845(2015)
