Nanaomycin A
Cat. No.：YN250091
| 产品名称: | Nanaomycin A |
| CAS No.: | 52934-83-5 |
| Chemical Name: | (1S,3R)-3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid |
| Synonyms: | |
| 分子量: | 302.28 |
| 分子式: | C₁₆H₁₄O₆ |
| SMILES: | O=C(O)C[C@H]1CC(C(C2=C3C(O)=CC=C2)=O)=C(C3=O)[C@H](C)O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nanaomycin A 是第一个选择性DNMT3B抑制剂，IC50为 500 nM。Nanaomycin A 是一种醌类抗生素，可重新激活人类癌细胞中沉默的抑癌基因。Nanaomycin A 抑制人疟原虫恶性疟原虫的体外生长，IC80值为 33.1 nM。 |
| IC50和靶点: | [{name:"DNMT3B:500 nM (IC50)'}, 'Plasmodium'] |
| In Vitro: | |
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| Solvent & Solubility: |
Iwai, Y., Kimura, K., Takahashi, Y., et al.OM-173, new nanaomycin-type antibiotics produced by a strain of Streptomyces. Taxonomy, production, isolation and biological propertiesJ. Antibiot. (Tokyo)36(10),1268-1274(1983)
Tanaka, T., Kamei, K., Otoguro, K., et al.Heme-dependent radical generation: Possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicolJ. Antibiot. (Tokyo)52(10),880-888(1999)
Kuck, D., Caulfield, T., Lyko, F., et al.Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cellsMol. Cancer Ther.9(11),3015-3023(2010)
Nakamae, S., Toba, Y., Takayama, K., et al.Nanaomycin A treatment promotes hepatoblast differentiation from human induced pluripotent stem cellsStem Cells Dev.27(6),405-414(2018)
