Obatoclax
Cat. No.：YN250185
| 产品名称: | Obatoclax |
| CAS No.: | 803712-67-6 |
| Chemical Name: | |
| Synonyms: | GX15-070 |
| 分子量: | 317.38 |
| 分子式: | C₂₀H₁₉N₃O |
| SMILES: | COC1=CC(C(N2)=CC3=C2C=CC=C3)=N/C1=C\C4=C(C)C=C(C)N4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Obatoclax (GX15-070) 是 BH3 模拟物，是泛BCL-2家族蛋白抑制剂，对 BCL-2 的Ki值为 220 nM。Obatoclax 诱导自噬 (autophagy) 依赖性细胞死亡，并靶向细胞周期蛋白 D1 进行蛋白酶体降解。Obatoclax 具有抗癌和广谱抗寄生虫 (antiparasitic) 活性。 |
| IC50和靶点: | [{name:"BCL2:200 nM (Ki)"},{name: "Mcl-1:1-7 μM (Ki)"},{name: "Bcl-xL:1-7 μM (Ki)"},{name: "Bcl-W:1-7 μM (Ki)"},{name: "Bcl-B:1-7 μM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
