Quinacrine dihydrochloride
Cat. No.：YN250559
| 产品名称: | Quinacrine dihydrochloride |
| CAS No.: | 69-05-6 |
| Chemical Name: | N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-,1,4-pentanediamine Hydrochloride; N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine Dihydrochloride; 6-Chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxy-,acridine Dihydrochlori |
| Synonyms: | 阿的平; Mepacrine dihydrochloride; SN-390 dihydrochloride |
| 分子量: | 472.88 |
| 分子式: | C₂₃H₃₂Cl₃N₃O |
| SMILES: | CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Quinacrine (Mepacrine) dihydrochloride 是一种有效的，具有口服活性的抗疟剂 (antimalarial)，在体内外均具有抗肿瘤作用。Quinacrine dihydrochloride 抑制 NF-κB 并激活 p53 信号转导，诱导肿瘤细胞发生凋亡 (apoptosis)。 |
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Bockelmann, S., et al.: J. Biol. Chem., 285, 38304 (2010)
Wrench, A., et al.: PLoS ONE, 8, e54498 (2013)
Kasymov, V., et al.: J. Neuroscience, 33, 435 (2013)
Mori, T., et al.: Biol. Pharm. Bull., 35, 2243 (2012)
