Fexinidazole
Cat. No.：YN250568
CAS No. ：59729-37-2
| 产品名称: | Fexinidazole |
| CAS No.: | 59729-37-2 |
| Chemical Name: | 1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-1H-imidazole |
| Synonyms: | 非昔硝唑; HOE 239 |
| 分子量: | 279.31 |
| 分子式: | C₁₂H₁₃N₃O₃S |
| SMILES: | O=[N+](C1=CN=C(COC2=CC=C(SC)C=C2)N1C)[O-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fexinidazole (HOE 239) 是一种具有口服活性的，有效的硝基咪唑抗锥虫药物。Fexinidazole 显示出对布鲁氏杆菌 (T. brucei) 亚种和菌株的杀锥虫活性，IC50值为 0.7-3.3 μM (0.2-0.9 μg/ml)。Fexinidazole 具有用于因感染布鲁氏菌引起的人类昏睡病 (HAT) 的潜力。 |
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Su, L., Pan, P., Yan, P., et al.Role of vimentin in modulating immune cell apoptosis and infammatory responses in sepsisSci. Rep.9(1),5747(2019)
Wyllie, S.G., Patterson, S., Stojanovski, L., et al.The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasisSci. Transl. Med.4(119),119re111(2012)
Bahia, M.T., de Andrade, I.M., Martins, T.A.F., et al.Fexinidazole: A potential new drug candidate for Chagas diseasePLoS Negl. Trop. Dis.6(11),e1870(2012)
