Mebendazole
Cat. No.：YN250767
| 产品名称: | Mebendazole |
| CAS No.: | 31431-39-7 |
| Chemical Name: | N-(6-benzoyl-1H-benzimidazol-2-yl)-carbamic acid, methyl ester |
| Synonyms: | 甲苯咪唑 |
| 分子量: | 295.29 |
| 分子式: | C₁₆H₁₃N₃O₃ |
| SMILES: | O=C(OC)NC1=NC2=CC=C(C(C3=CC=CC=C3)=O)C=C2N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Mebendazole是一高效广谱驱虫药，同时也被报道是hedgehog抑制剂。 |
| IC50和靶点: | |
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Seo, B.S., Cho, S.Y., Kang, S.Y., et al.Anthelmintic efficacy of methyl-5-benzoylbenzimidazole-2-carbamate(mebendazole) against multiple helminthic infectionsKorean J. Parasitol.15(1),11-16(1977)
Morgan, U.M., Reynoldson, J.A., and Thompson, R.C.A.Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitroAntimicrob. Agents Chemother.37(2),328-331(1993)
Doudican, N., Rodriguez, A., Osman, I., et al.Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cellsMol. Cancer Res.6(8),1308-1315(2008)
Mukhopadhyay, T., Sasaki, J.i., Ramesh, R., et al.Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivoClin. Cancer Res.8(9),2963-2969(2002)
Sasaki, J.i., Ramesh, R., Chada, S., et al.The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cellsMol. Cancer Ther.1(13),1201-1209(2016)
Larsen, A.R., Bai, R.Y., Chung, J.H., et al.Repurposing the antihelmintic mebendazole as a hedgehog inhibitorMol. Cancer Ther.14(1),3-13(2015)
Aleyasin, H., Karuppagounder, S.S., Kumar, A., et al.Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulinAntioxid. Redox Signal.22(2),121-134(2015)
