PK 11195
Cat. No.：YN250807
CAS No. ：85532-75-8
| 产品名称: | PK 11195 |
| CAS No.: | 85532-75-8 |
| Chemical Name: | 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide |
| Synonyms: | RP 52028 |
| 分子量: | 352.86 |
| 分子式: | C₂₁H₂₁ClN₂O |
| SMILES: | O=C(N(C(CC)C)C)C1=CC2=CC=CC=C2C(C3=CC=CC=C3Cl)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PK 11195 (RP 52028) 是TSPO的一个配体，可靶向研究利什曼病，其对L. amazonensis，L. major和L. braziliensis的IC50值分别为 14.2 μM, 8.2 μM, 3.5 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Watanabe, Y., Shibuya, T., Khatami, S., et al.Comparison of typical and atypical benzodiazepines on the central and peripheral benzodiazepine receptorsJpn. J. Pharmacol.42(2),189-197(1986)
Pike, V.W., Halldin, C., Crouzel, C., et al.Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites-current statusNucl. Med. Biol.20(4),503-525(1993)
Olson, J.M.M., Junck, L., Young, A.B., et al.Isoquinoline and peripheral-type benzodiazepine binding in gliomas: Implications for diagnostic imagingCancer Res.48(20),5837-5841(1988)
Guo, Y., Kalathur, R.C., Liu, Q., et al.Protein structure. Structure and activity of tryptophan-rich TSPO proteinsScience347(6221),551-555(2015)
