Sitamaquine tosylate
Cat. No.：YN250813
| 产品名称: | Sitamaquine tosylate |
| CAS No.: | 1019640-33-5 |
| Chemical Name: | N1,N1-diethyl-N6-(6-methoxy-4-methyl-8-quinolinyl)-1,6-hexanediamine, 4-monomethylbenzenesulfonate |
| Synonyms: | WR 6026 tosylate |
| 分子量: | 515.71 |
| 分子式: | C₂₈H₄₁N₃O₄S |
| SMILES: | CC1=CC=NC2=C(NCCCCCCN(CC)CC)C=C(OC)C=C12.O=S(C3=CC=C(C)C=C3)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sitamaquine (WR 6026) tosylate 是一种具有口服活性 8-aminoquinoline 类似物，是一种抗利什曼病药物。Sitamaquine tosylate 是一种嗜脂性弱碱，在利什曼原虫的酸性区迅速积聚，主要集中在酸钙小体中。 |
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López-Martín, C., Pérez-Victoria, J.M., Carvalho, L., et al.Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomesAntimicrob. Agents Chemother.52(11),4030-4036(2008)
Carvalho, L.J.M., Luque-Ortega, J.R., López-Martín, C., et al.The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenaseAntimicrob. Agents Chemother.55(9),4204-4210(2011)
