Hycanthone
Cat. No.：YN251219
| 产品名称: | Hycanthone |
| CAS No.: | 3105-97-3 |
| Chemical Name: | 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)-9H-thioxanthen-9-one;1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)thioxanthen-9-one; Hycanthon; NCI 142982; NSC 134434; NSC 142982; Win 24933; |
| Synonyms: | 海恩酮 |
| 分子量: | 356.48 |
| 分子式: | C₂₀H₂₄N₂O₂S |
| SMILES: | O=C1C2=C(SC3=C1C=CC=C3)C(CO)=CC=C2NCCN(CC)CC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Hycanthone 是噻吨酮类的 DNA 嵌入剂 (DNA intercalator)，可抑制 RNA 合成以及 DNA 拓扑异构酶 I 和 II。Hycanthone 通过直接蛋白质结合来抑制核酸生物合成并抑制嘌呤内切核酸酶1 (APE1)，KD为 10 nM。Hycanthone 是 Lucanthone (HY-B2098) 的生物活性代谢产物，具有抗血吸虫病药物。 |
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Galitski, T., et al.: Science, 285, 251 (1999)
Bubb, M., et al.: J. Biol. Chem., 269, 14869 (1994)
Duncan, K., et al.: Biochem. Pharmacol., 52, 1553 (1996)
