Amodiaquine
Cat. No.：YN251291
| 产品名称: | Amodiaquine |
| CAS No.: | 86-42-0 |
| Chemical Name: | 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-phenol |
| Synonyms: | Amodiaquin |
| 分子量: | 355.86 |
| 分子式: | C₂₀H₂₂ClN₃O |
| SMILES: | OC1=CC=C(NC2=CC=NC3=CC(Cl)=CC=C23)C=C1CN(CC)CC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Amodiaquine (Amodiaquin) 是一种4-氨基喹啉类抗疟剂，是一种有效的具有口服活性的组胺 N-甲基转移酶 (histamine N-methyltransferase) 抑制剂。Amodiaquine 也是一种Nurr1激动剂，可特异性结合Nurr1的配体结合域，EC50为 ~20 μM。抗炎作用。 |
| IC50和靶点: | |
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Mariga, S.T., Gil, J.P., Sisowath, C., et al.Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitroAntimicrob. Agents Chemother.48(11),4089-4096(2004)
Sá, J.M., Chong, J.L., and Wellems, T.E.Malaria drug resistance: New observations and developmentsEssays Biochem.51,137-160(2014)
Jacobs, R.L., Alling, D.W., and Cantrell, W.F.An evaluation of antimalarial combinations against Plasmodium berghei in the mouseJ. Parasitol.49(6),920-925(1963)
