Benznidazol
Cat. No.：YN251336
| 产品名称: | Benznidazol |
| CAS No.: | 22994-85-0 |
| Chemical Name: | 2-nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide |
| Synonyms: | 苄硝唑; Ro 07-1051; Ro 71051 |
| 分子量: | 260.25 |
| 分子式: | C₁₂H₁₂N₄O₃ |
| SMILES: | O=C(NCC1=CC=CC=C1)CN2C=CN=C2[N+]([O-])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Benznidazol (Ro 07-1051) 是一种抗寄生虫药物，对哥伦比亚T. cruzi菌株的IC50值为 20.35 μM，有潜力用于美洲锥虫病的研究。 |
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Khare, S., Liu, W., Stinson, M., et al.Antitrypanosomal teatment with benznidazole is superior to posaconazole regimens in mouse models of Chagas diseaseAntimicrob. Agents Chemother.59(10),6385-6394(2015)
Trochine, A., Creek, D.J., Faral-Tello, P., et al.Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomicsPLoS Negl. Trop. Dis.8(5),e2844(2014)
Cogo, J., de Oliveira Caleare, A., Ueda-Nakamura, T., et al.Trypanocidal activity of guaianolide obtained from Tanacetum parthenium (L.) Schultz-Bip. and its combinational effect with benznidazolePhytomedicine20(1),59-66(2012)
Hernández-Núñez, E., Tlahuext, H., Moo-Puc, R., et al.Design, synthesis and biological evaluation of 2-(2-amino-5(6)-nitro-1H-benzimidazol-1-yl)-N-arylacetamides as antiprotozoal agentsMolecules22(4),E579(2017)
Li, Q., Lin, Q., and Yun, Z.Hypoxia-activated cytotoxicity of benznidazole against clonogenic tumor cellsCancer Biol. Ther.17(12),1266-1273(2016)
