Asiatic acid
Cat. No.：YN251449
CAS No. ：464-92-6
| 产品名称: | Asiatic acid |
| CAS No.: | 464-92-6 |
| Chemical Name: | (4α)-2α,3β,23-trihydroxy-urs-12-en-28-oic acid |
| Synonyms: | Dammarolic acid, Asiantic acid |
| 分子量: | 488.70 |
| 分子式: | C₃₀H₄₈O₅ |
| SMILES: | C[C@@]1(CO)[C@@H](O)[C@H](O)C[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Asiatic acid，是在Centella asiatica中发现的一种五环三萜，可诱导黑色素瘤细胞的凋亡，有用于皮肤癌的潜能。Asiatic acid 还拥有抗炎活性。 |
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Maquart, F.X., Chastang, F., Simeon, A., et al.Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental woundsEur. J. Dermatol.9(4),289-296(1999)
Hsu, Y.L., Kuo, P.L., Lin, L.T., et al.Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cellsJ. Pharmacol. Exp. Ther.313(1),333-344(2005)
Kavitha, C.V., Agarwal, C., Agarwal, R., et al.Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture modelsPLoS One6(8),(2011)
Patil, S.P., Maki, S., Khedkar, S.A., et al.Withanolide A and asiatic acid modulate multiple targets associated with amyloid-β precursor protein processing and amyloid-β protein clearanceJ. Nat. Prod.73(7),1196-1202(2010)
Xu, M.F., Xiong, Y.Y., Liu, J.K., et al.Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cellsActa Pharmacol. Sin.33,578-587(2012)
