Acivicin
Cat. No.：YN251933
| 产品名称: | Acivicin |
| CAS No.: | 42228-92-2 |
| Chemical Name: | αS-amino-3-chloro-4,5S-dihydro-5-isoxazoleacetic acid |
| Synonyms: | 阿西维辛; AT-125; U-42126 |
| 分子量: | 178.57 |
| 分子式: | C₅H₇ClN₂O₃ |
| SMILES: | ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Acivicin (AT-125) 是一种由猪链霉菌产生的天然产物，是 γ-谷氨酰转肽酶 (GGT) 抑制剂。Acivicin 可以透过血脑屏障，并具有抗癌，抗寄生虫的特性。 |
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Tso, J.Y., Bower, S.G., and Zalkin, H.Mechanism of inactivation of glutamine amidotransferases by the antitumor drug L-(αS, 5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125)J. Biol. Chem.255(14),6734-6738(1980)
Lyons, S.D., Sant, M.E., and Christopherson, R.I.Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemiaJ. Biol. Chem.265(19),11377-11381(1990)
Stole, E., Smith, T.K., Manning, J.M., et al.Interaction of γ-glutamyl transpeptidase with acivicinJ. Biol. Chem.269(34),21435-21439(1994)
Smith, T.K., Ikeda, Y., Fujii, J., et al.Different sites of acivicin binding and inactivation of γ-glutamyl transpeptidasesProc. Natl. Acad. Sci. USA92,2360-2364(1995)
Griffith, O.W., and Meister, A.Excretion of cysteine and γ-glutamylcysteine moieties in human and experimental animal γ-glutamyl transpeptidase deficiencyProc. Natl. Acad. Sci. USA77(6),3384-3387(1980)
Meck, R.A., Clubb, K.J., Allen, L.M., et al.Inhibition of cell cycle progression of human pancreatic carcinoma cells in vitro by L-(αS,5S)-α-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, acivicin (NSC 163501)Cancer Res.41,4547-4553(1981)
Willoughby, L.F., Schlosser, T., Manning, S.A., et al.An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discoveryDis. Model. Mech.6(2),521-529(2012)
