IWP-O1
Cat. No.：YN450013
CAS No. ：2074607-48-8
规格
价格(RMB)
库存
| 产品名称: | IWP-O1 |
| CAS No.: | 2074607-48-8 |
| Chemical Name: | 5-phenyl-N-(5-phenyl-2-pyridinyl)-4-(4-pyridinyl)-1H-1,2,3-triazole-1-acetamide |
| Synonyms: | |
| 分子量: | 432.48 |
| 分子式: | C₂₆H₂₀N₆O |
| SMILES: | O=C(CN1N=NC(C2=CC=NC=C2)=C1C3=CC=CC=C3)NC4=NC=C(C5=CC=CC=C5)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IWP-O1 是一个有效的Porcn抑制剂，在 L-Wnt-STF 细胞中的EC50值为 80 pM。IWP-O1 抑制Wnt蛋白分泌。IWP-O1 能够抑制 HeLa 细胞中 Dvl2/3 和 LRP6 磷酸化。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
You, L., Zhang, C., Yarravarapu, N., et al.Development of a triazole class of highly potent Porcn inhibitorsBioorg. Med. Chem. Lett.26(24),5891-5895(2016)
Kleszcz, R., and Paluszczak, J.The Wnt signaling pathway inhibitors improve the therapeutic activity of glycolysis modulators against tongue cancer cellsInt. J. Mol. Sci.23(3),1248(2022)
