Porcn-IN-1
Cat. No.：YN450037
CAS No. ：2036044-77-4
规格
价格(RMB)
库存
| 产品名称: | Porcn-IN-1 |
| CAS No.: | 2036044-77-4 |
| Chemical Name: | N-[(3-fluoro-2'-methyl[2,4'-bipyridin]-5-yl)methyl]-9H-carbazole-2-carboxamide |
| Synonyms: | Porcupine-IN-1 |
| 分子量: | 410.44 |
| 分子式: | C₂₅H₁₉FN₄O |
| SMILES: | FC1=C(C2=CC(C)=NC=C2)N=CC(CNC(C3=CC=C(C(C=CC=C4)=C4N5)C5=C3)=O)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Porcn-IN-1 是有效的porcupine抑制剂，IC50值为 0.5±0.2 nM。 |
| IC50和靶点: | |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Xu, Z., Xu, X., O'Laoi, R., et al.Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffoldBioorg. Med. Chem.24(22),5861-5872(2016)
Ma, H., Chen, Q., Zhu, F., et al.Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitorEur. J. Med. Chem.149,110-121(2018)
